Research Interests

My background in ecology and evolution has strongly influenced my research interests. The broad questions on processes and interactions within evolutionary systems are what interest me most. Modern high-throughput sequencing is an excellent tool to explore natural variation since it provides unparalleled resolution into the evolutionary process. While my undergraduate studies focused on organismal evolution and ecology, my postgraduate studies sparked my interest in investigating the evolutionary process on a microscopic scale. My postgraduate experience is provided me insight into evolution within an organism when looking at the genesis and evolution of cancer within a patient.

My research interests are now also underpinned by my enjoyment for writing software and creating tools for others to use. This has involved the sole development of, and contribution to, many internal and external pipelines, tools and platforms within the field of bioinformatics.

Publications (* Indicates first authorship)

* Leong, T.L. & Gayevskiy, V. & Steinfort, D.P. & De Massy, M.R. et al (2018). Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer. Oncogene (preprint). DOI: 10.1038/s41388-018-0536-1 | PDF

* Gayevskiy, V. & Roscioli, T. & Dinger, M.E. & Cowley, M.J. (2018). Seave: a comprehensive web platform for storing and interrogating human genomic variation. Bioinformatics (preprint). DOI: 10.1093/bioinformatics/bty540 | PDF | bioRxiv | GitHub

Tsoli M. & Wadham C. & Pinese M. & Failes T. & Joshi S. & Mould E. & Yin J.X. & Gayevskiy V. et al (2018). Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer. Cancer Biology & Therapy (preprint). DOI: 10.1080/15384047.2018.1491498 | PDF

Barnet M. & Jackson K. & Gao B. & Nagrial A. & Boyer M. & Cooper W. & Hui R. & Linton A. & Tattersall M. & Russell A. & Gibson G. & Cebon J. & Long G. & Menzies A. & Scolyer R. & Lacaze P. & Brink R. & Peters T. & Cowley M. & Gayevskiy V. et al (2018). Exploring the Germ-Line Contribution to Exceptional Response to PD-1/PD-L1 Inhibition in Patients with NSCLC by Whole Genome Sequencing. Journal of Thoracic Oncology, 13 (10), pp. S529. DOI: 10.1016/j.jtho.2018.08.726 | PDF

Ziegler D.S. & Wong M. & Mayoh C. & Kumar A. & Tsoli M. & Mould E. & Tyrrell V. & Khuong-Quang D.A. & Pinese M. & Gayevskiy V. et al (2018). Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma. British Journal of Cancer, 119, pp. 693-696. DOI: 10.1038/s41416-018-0251-2 | PDF

Kumar, K. & Wali, G. & Davis, R. & Mallawaarachchi, A. & Palmer, E. & Gayevskiy, V. et al (2018). Expanding the spectrum of PEX16 mutations and novel insights into disease mechanisms. Molecular Genetics and Metabolism Reports, 16, pp. 46-51. DOI: 10.1016/j.ymgmr.2018.07.003 | PDF

Kirk E.P. & Barlow-Stewart K. & Selvanathan A. & Josephi-Taylor S. & Worgan L. & Rajagopalan S. & Cowley M.J. & Gayevskiy V. et al (2018). Beyond the panel: preconception screening in consanguineous couples using the TruSight One "clinical exome". Genetics in Medicine (preprint). DOI: 10.1038/s41436-018-0082-9 | PDF

Minoche, A.E. & Horvat, C. & Johnson, R. & Gayevskiy, V. et al (2018). Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. Genetics in Medicine (preprint). DOI: 10.1038/s41436-018-0084-7 | PDF

Ewans, L.J. & Schofield, D. & Shrestha, R. & Zhu, Y. & Gayevskiy, V. et al (2018). Whole-exome sequencing reanalysis at 12 months boosts diagnosis and is cost-effective when applied early in Mendelian disorders. Genetics in Medicine (preprint). DOI: 10.1038/gim.2018.39 | PDF

De Sousa, S.M. & McCabe, M.J. & Wu, K. & Roscioli, T. & Gayevskiy, V. et al (2017). Germline variants in familial pituitary tumour syndrome genes are common in young patients and families with additional endocrine tumours. European Journal of Endocrinology, 176 (5), pp. 635-644. DOI: 10.1530/EJE-16-0944 | PDF

Balasubramaniam, S. & Riley, L.G. & Vasudevan, A. & Cowley, M.J. & Gayevskiy, V. & Sue, C.M. & Edwards, C. & Edkins, E. & Junckerstorff, R. & Kiraly-Borri, C. & Rowe, P. & Christodoulou, J. (2017). EPG5-Related Vici Syndrome: A Primary Defect of Autophagic Regulation with an Emerging Phenotype Overlapping with Mitochondrial Disorders. JIMD Reports. DOI: 10.1007/8904_2017_71 | PDF

Balasubramaniam, S. & Riley, L. & Bratkovic, D. & Ketteridge, D. & Manton, N. & Cowley, M.J. & Gayevskiy, V. & Roscioli, T. & Mohamed, M. & Gardeitchik, T. & Morava, E. & Christodoulou, J. (2017). Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency. Journal of Inherited Metabolic Disease, 40 (5), pp. 745-747. DOI: 10.1007/s10545-017-0036-4 | PDF

Riley, L.R. & Cowley, M.J. & Gayevskiy, V. et al (2017). A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders. Journal of Inherited Metabolic Disease, 40 (2), pp. 261-269. DOI: 10.1007/s10545-016-0010-6 | PDF

Heimer, G. et al. (2016). MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder. The American Journal for Human Genetics, 99 (6), pp. 1229-1244. DOI: 10.1016/j.ajhg.2016.09.021 | PDF

* Gayevskiy, V. & Lee, S. & Goddard, M.R. (2016). European derived Saccharomyces cerevisiae colonisation of New Zealand vineyards aided by humans. FEMS Yeast Research, 16 (7), fow091. DOI: 10.1093/femsyr/fow091 | PDF

Kumar, K.R. et al. (2016). Defining the genetic basis of early onset hereditary spastic paraplegia using whole genome sequencing. Neurogenetics, 17, pp. 265-270. DOI: 10.1007/s10048-016-0495-z | PDF

Merlevede, J. et al. (2016) Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents. Nature Communications, 7:10767 DOI: 10.1038/ncomms10767 | PDF

* Gayevskiy, V. & Goddard, M.R. (2016) Saccharomyces eubayanus and Saccharomyces arboricola reside in North Island native New Zealand forests. Environmental Microbiology, 18 (4), pp. 1137-1147. DOI: 10.1111/1462-2920.13107 | PDF

Rogers, S. & McCloy, R. & Parker, B. & Chaudhuri, R. & Gayevskiy, V. & Hoffman, N. & Watkins, D. & Daly, R. & James, D. & Burgess, A. (2015). Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells. Data in Brief, 5, pp. 45-52. DOI: 10.1016/j.dib.2015.08.010 | PDF

McCloy, R. & Parker, B. & Rogers, S. & Chaudhuri, R. & Gayevskiy, V. & Hoffman, N. & Ali, N. & Watkins, N. & Daly, R. & James, D. et al (2015). Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs. Molecular and Cellular Proteomics, 14 (8), pp. 2194-2212. DOI: 10.1074/mcp.M114.046938 | PDF

* Gayevskiy V. & Klaere S. & Knight S. & Goddard M.R. (2014) ObStruct: A Method to Objectively Analyse Factors Driving Population Structure Using Bayesian Ancestry Profiles. PLoS ONE, 9 (1): e85196. DOI: 10.1371/journal.pone.0085196 | PDF

* Gayevskiy, V. & Goddard, M.R. (2012). Geographic delineations of yeast communities and populations associated with vines and wines in New Zealand. The ISME Journal, 6 (7), pp. 1281-1290. DOI: 10.1038/ismej.2011.195 | PDF

Conferences

2016 - AGTA Conference Poster

2015 - AGTA Conference Poster

2014 - NZMEC Symposium Talk

2014 - NZ Phylogenomics Meeting Talk

2011 - Romeo Bragato Conference Talk

2010 - New Zealand Microbiological Society (NZMS) Conference Talk

Teaching

2017 - Taught the sections on cancer genomics, bioinformatics for clinicians, introduction to Seave and copy number/structural variants at the Clinical Genomics Workshop hosted by the Kinghorn Centre for Clinical Genomics in Hong Kong. Ran two practical workshop sessions on using Seave to diagnose patients with rare disease and validate variants using IGV.

2016 - Taught the copy number variation and variant filtration sections of the Cancer Genomics Workshop hosted by BioPlatforms Australia in Melbourne.

2015 - Taught the copy number variation and variant filtration sections of the Cancer Genomics Workshop hosted by BioPlatforms Australia in Canberra.

2015 - Short talk on Seave at the Clinical Genomics workshop hosted at the Kinghorn Centre for Clinical Genomics.